Endocrine Abstracts

We have previously demonstrated that a low dose of hydrocortisone (100 mg) given intravenously suppresses intranuclear NFκB and AP-1 binding and the expression of pro-inflammatory genes like MMPs. We have now investigated the effect of a high dose of hydrocortisone (300 mg=60 mg prednisolone) on NFκB binding and the expression of TLRs, the mediators of TLR signal transduction, MyD88 and TRIF and HMG-B1. Ten normal subjects were injected intravenously with 300 mg of h...

We describe the course of a now 24y/o M with congenital hypopituitarism, severe micropenis, cryptorchidism, hypoplastic testes, hypospadiasis and pulmonic stenosis. He presented with neonatal hypoglycemia. MRI showed small anterior pituitary and ectopic posterior pituitary near tuberous cinereum. Pulmonic stenosis detected after auscultation of a murmur, was mild grade on echo. Free T4 1 ng/dl (1–2.5) TSH 6.7 μU/ml (0.2–6) glucagon stimulation for GH ...

Our previous work has shown that the intake of a high fat high carbohydrate (HFHC) meal results in an increase in endotoxin (LPS) and LPS binding protein (LBP) concentrations concomitant with an increase in the expression of TLR-4, the receptor for LPS, and CD-14, which facilitates the binding of LPS to its receptor. In addition, there is an increase in ROS generation, NFkB binding and the expression of TNF-α and IL-1β. Our work has also demonstrated that an equicalo...